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Unlike THC, CBD isn’t psychoactive, which means it doesn’t cause a mental “high.” While there’s little research on the side effects of vaping CBD, some general side effects — which tend to be mild — of CBD use include: irritability fatigue nausea diarrhea Vaping flavored CBD oil may also cause side effects similar to those of nicotine-free e-cigarettes, depending on the fluid’s base and flavoring ingredients